Background. In this study, 18 methanol extracts from Cameroonian edible plants were tested for their antibacterial\nactivities against 26 strains of S. aureus; the role of efflux pumps in the resistance of tested bacteria and the antibiotic\nresistance-modulating activities against selected multidrug-resistant (MDR) phenotypes were also investigated. Methods.\nBroth microdilution assay was used to evaluate the antibacterial activity, the role of efflux pumps, and the antibiotic\nresistance-modulating effects of plant extracts. Results. Extracts from Dacryodes edulis seeds (DES) and Dacryodes edulis\nbark (DEB) were active against all 26 tested bacterial strains, within the minimal inhibitory concentration (MIC) range of\n256ââ?¬â??1024 Ã?¼g/mL. MIC values varied from 64 to 1024 Ã?¼g/mL against 96.2% of the 26 tested bacteria for Phaseolus vulgaris\nleaves (PVL), 92.3% for Azadirachta indica bark (AIB), Dacryodes edulis leaves (DEL), and Ricinodendron heudelotii\nleaves (RHL). The lowest MIC value of 64 Ã?¼g/mL was obtained with the extract from Cucurbita maxima beans (CMB)\nagainst MRSA4 strain and from Uapaca guineensis bark (UGB) against MRSA9 strain. Bacterial efflux pump inhibitor\n(EPI), carbonyl cyanide m-chlorophenyl hydrazone (CCCP), improved the activity of DES and UGB as well as that of\nextracts from Hibiscus esculentus leaves (HEL) and Uapaca guineensis leaves (UGL) against resistant S. aureus strains.\nAntibiotic-modulating effects against more than 70% of the S. aureus strains tested were obtained when RHL (at MIC/2)\nwas combined with CIP, ERY, and KAN (88.89%), CHL (88.89%), TET (77.78%), and STR (88.89%). Conclusion. The\npresent study demonstrated that the 13 tested plants had antistaphylococcal effects and that DES, HEL, UGL, and UGB\ncould be used in combination with EPI to combat resistance to Staphylococcus aureus. Also, it demonstrated that some\nstudied extracts and mostly RHL could be used as antibiotic resistance modulators to fight against resistant strains of\nS. aureus.
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